The perfect execution of a voluntary movement requires the appropriate integration of current bodily state, sensory input and desired outcome. To assure that this motor output becomes and remains appropriate, the brain needs to learn from the result of previous outputs. The cerebellum plays a central role in sensorimotor integration, yet -despite decades of work- there is no generally excepted theory for cerebellar functioning.
We recently demonstrated that cerebellar modules, identified based on anatomical connectivity and gene expression, differ distinctly in spiking activity properties. It is our long-term goal to reveal the anatomical and physiological differences between modules and their functional consequences in development, adulthood and disease.
- Plasticity mechanisms underlying cerebellum-dependent adaptation
- Cerebellar cortical information processing in individual modules
- The origin of modular differences in cerebellar cortical activity