Publications

2010 - 2017

Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction.
Voges K, Wu B, Post L, Schonewille M, De Zeeuw CI.
J Physiol. 2017 Jun 6. doi: 10.1113/JP274346. [Epub ahead of print]

Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.
Badura A, Clopath C, Schonewille M, De Zeeuw CI.
Sci Rep. 2016 Nov 2;6:36131. doi: 10.1038/srep36131.

Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice.
Peter S, Ten Brinke MM, Stedehouder J, Reinelt CM, Wu B, Zhou H, Zhou K, Boele HJ, Kushner SA, Lee MG, Schmeisser MJ, Boeckers TM, Schonewille M, Hoebeek FE, De Zeeuw CI.
Nat Commun. 2016 Sep 1;7:12627. doi: 10.1038/ncomms12627.

SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination.
Rahmati N, Vinueza Veloz MF, Xu J, Barone S, Rodolfo Ben Hamida N, Schonewille M, Hoebeek FE, Soleimani M, De Zeeuw CI.
eNeuro. 2016 Jun 15;3(3). pii: ENEURO.0028-16.2016.

Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model.
Bruinsma CF, Schonewille M, Gao Z, Aronica EM, Judson MC, Philpot BD, Hoebeek FE, van Woerden GM, De Zeeuw CI, Elgersma Y.
J Clin Invest. 2015 Nov 2;125(11):4305-15. doi: 10.1172/JCI83541. Epub 2015 Oct 20.

Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS.
Hukema RK, Buijsen RA, Schonewille M, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Verhagen RF, van Dessel L, Maas A, Charlet-Berguerand N, De Zeeuw CI, Hagerman PJ, Berman RF, Willemsen R.
Hum Mol Genet. 2015 Sep 1;24(17):4948-57. doi: 10.1093/hmg/ddv216. Epub 2015 Jun 9.

Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules.
Zhou H, Voges K, Lin Z, Ju C, Schonewille M.
J Neurophysiol. 2015 Apr 1;113(7):2524-36. doi: 10.1152/jn.00925.2014. Epub 2015 Feb 25.

Cerebellar modules operate at different frequencies.
Zhou H, Lin Z, Voges K, Ju C, Gao Z, Bosman LW, Ruigrok TJ, Hoebeek FE, De Zeeuw CI, Schonewille M.
Elife. 2014 May 7;3:e02536. doi: 10.7554/eLife.02536.

Familial Alzheimer’s disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis.
Sepulveda-Falla D, Barrera-Ocampo A, Hagel C, Korwitz A, Vinueza-Veloz MF, Zhou K, Schonewille M, Zhou H, Velazquez-Perez L, Rodriguez-Labrada R, Villegas A, Ferrer I, Lopera F, Langer T, De Zeeuw CI, Glatzel M.
J Clin Invest. 2014 Apr;124(4):1552-67. doi: 10.1172/JCI66407. Epub 2014 Feb 24.

T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.
Ly R, Bouvier G, Schonewille M, Arabo A, Rondi-Reig L, Léna C, Casado M, De Zeeuw CI, Feltz A.
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20302-7. doi: 10.1073/pnas.1311686110. Epub 2013 Nov 25.

Gating of long-term potentiation by nicotinic acetylcholine receptors at the cerebellum input stage.
Prestori F, Bonardi C, Mapelli L, Lombardo P, Goselink R, De Stefano ME, Gandolfi D, Mapelli J, Bertrand D, Schonewille M, De Zeeuw C, D’Angelo E.
PLoS One. 2013 May 31;8(5):e64828. doi: 10.1371/journal.pone.0064828. Print 2013.

Climbing fiber input shapes reciprocity of Purkinje cell firing.
Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI.
Neuron. 2013 May 22;78(4):700-13. doi: 10.1016/j.neuron.2013.03.018. Epub 2013 May 2.

Silencing the majority of cerebellar granule cells uncovers their essential role in motor learning and consolidation.
Galliano E, Gao Z, Schonewille M, Todorov B, Simons E, Pop AS, D’Angelo E, van den Maagdenberg AM, Hoebeek FE, De Zeeuw CI.
Cell Rep. 2013 Apr 25;3(4):1239-51. doi: 10.1016/j.celrep.2013.03.023. Epub 2013 Apr 11.

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Hübner CA, De Zeeuw CI, Jentsch TJ.
EMBO J. 2012 Mar 7;31(5):1217-30. doi: 10.1038/emboj.2011.488. Epub 2012 Jan 17.

Spatiotemporal firing patterns in the cerebellum.
De Zeeuw CI, Hoebeek FE, Bosman LW, Schonewille M, Witter L, Koekkoek SK.
Nat Rev Neurosci. 2011 Jun;12(6):327-44. doi: 10.1038/nrn3011. Epub 2011 May 5. Review.

Reevaluating the role of LTD in cerebellar motor learning.
Schonewille M
, Gao Z, Boele HJ, Veloz MF, Amerika WE, Simek AA, De Jeu MT, Steinberg JP, Takamiya K, Hoebeek FE, Linden DJ, Huganir RL, De Zeeuw CI.
Neuron. 2011 Apr 14;70(1):43-50. doi: 10.1016/j.neuron.2011.02.044.

Cerebellar molecular layer interneurons – computational properties and roles in learning.
Jörntell H, Bengtsson F, Schonewille M, De Zeeuw CI.
Trends Neurosci. 2010 Nov;33(11):524-32. doi: 10.1016/j.tins.2010.08.004. Epub 2010 Sep 24. Review. Erratum in: Trends Neurosci. 2011 Mar;34(3):113.

Genetic dissection of the function of hindbrain axonal commissures.
Renier N, Schonewille M, Giraudet F, Badura A, Tessier-Lavigne M, Avan P, De Zeeuw CI, Chédotal A.
PLoS Biol. 2010 Mar 9;8(3):e1000325. doi: 10.1371/journal.pbio.1000325

2000 - 2009

Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Wulff P, Schonewille M, Renzi M, Viltono L, Sassoè-Pognetto M, Badura A, Gao Z, Hoebeek FE, van Dorp S, Wisden W, Farrant M, De Zeeuw CI.Nat Neurosci. 2009 Aug;12(8):1042-9. doi: 10.1038/nn.2348. Epub 2009 Jul 5.

Causes and consequences of oscillations in the cerebellar cortex. De Zeeuw CI, Hoebeek FE, Schonewille M. Neuron. 2008 Jun 12;58(5):655-8. doi: 10.1016/j.neuron.2008.05.019.

Regular patterns in cerebellar Purkinje cell simple spike trains. Shin SL, Hoebeek FE, Schonewille M, De Zeeuw CI, Aertsen A, De Schutter E.PLoS One. 2007 May 30;2(5):e485.

Zonal organization of the mouse flocculus: physiology, input, and output. Schonewille M, Luo C, Ruigrok TJ, Voogd J, Schmolesky MT, Rutteman M, Hoebeek FE, De Jeu MT, De Zeeuw CI.J Comp Neurol. 2006 Aug 1;497(4):670-82.

Purkinje cells in awake behaving animals operate at the upstate membrane potential. Schonewille M, Khosrovani S, Winkelman BH, Hoebeek FE, De Jeu MT, Larsen IM, Van der Burg J, Schmolesky MT, Frens MA, De Zeeuw CI.Nat Neurosci. 2006 Apr;9(4):459-61; author reply 461. No abstract available.

Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice. Kuo JJ, Schonewille M, Siddique T, Schults AN, Fu R, Bär PR, Anelli R, Heckman CJ, Kroese AB.J Neurophysiol. 2004 Jan;91(1):571-5. Epub 2003 Oct 1.